According to experts at a KFAS-affiliated institution, more awareness of uncommon, hereditary types of diabetes is needed across the Middle East and North Africa (MENA) in order for patients to receive the best possible therapy.
People with maturity-onset diabetes of the young (MODY) are frequently misdiagnosed, according to experts at the Dasman Diabetes Institute in Kuwait City, since many clinicians are ignorant of how it varies from more prevalent types of the condition.
When compared to the more frequent type 1 and type 2 diabetes, MODY is an uncommon and lesser-known kind of diabetes. It's a hereditary condition that tends to run in families and manifests itself at an early age.
Professor Fahd Al-Mulla and colleagues, in a letter published in The Lancet Diabetes & Endocrinology, asked for more awareness of MODY and improved access to genetic testing in Kuwait.
The Middle East and North Africa (MENA) area has among of the world's highest diabetes rates. In Kuwait, one in every seven individuals has type 1 diabetes, and the number of children diagnosed with the disease has increased during the 1990s.
MODY, unlike type 1 and type 2 diabetes, is 'monogenic' disease, meaning it is caused by a single gene mutation. If one of the causative gene mutations exists in one of the parents, their offspring have a 50% risk of inheriting the disease.
Because the condition is so uncommon and its symptoms are so "It's critical to raise awareness of monogenic forms of the illness so that patients may be referred for genetic testing and receive appropriate care and therapy," says Dr. Hessa Al-Kandari, the Dasman Diabetes Institute's head of public health.
Definitive diagnosis also allows for better management of accompanying problems. HNF1-beta, one kind of MODY, is linked to renal disease, uterine abnormalities, and gout, among other things. similar to those of type 1 and type 2 diabetes, clinicians sometimes misdiagnose it as one of the two more prevalent types. However, the situation necessitates a different approach. The majority of patients, for example, do not require insulin or only require minimal dosages. It's normally treated with a combination of lifestyle modifications, weight loss, and oral medications.
Genetic testing also enables for better care of relatives with MODY who may not be aware of it. Children born to parents from the same extended family may have a higher chance of developing hereditary diabetes.
MODY's prevalence in Kuwait is yet undefined. Al-Mulla, Al-Kandari, and colleagues found multiple forms of the illness among 60 patients whose symptoms suggested they could have it in a research expected out later this year. They intend to open a MODY clinic at the Dasman Diabetes Institute to enhance diabetes diagnosis, management, and therapy and close the gap in Kuwaiti diabetes control.
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