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How COVID-19 Can Lead to Diabetes

By now, you might be aware of the health concerns caused by SARS-CoV-2, the COVID-19 virus. After some studies conducted, it has been identified that some people can develop diabetes after an acute COVID-19 infection.



Type 1 diabetes happens when pancreatic beta cells don't produce sufficient insulin to help the body metabolize food optimally after a meal. As a consequence of this insulin shortage, blood glucose levels go up the hallmark of diabetes. The previously conducted lab studies had indicated that SARS-CoV-2 can contaminate human beta cells. It also shows that this destructive virus can reproduce in these insulin-producing beta cells to make more replicas of itself and get distributed to other cells. 


The new discoveries tells that the coronavirus infection alters the operation of islets—the pancreatic tissue that has beta cells. Infection with SARS-CoV-2 leads to lowered production and release of insulin from pancreatic islet tissue. It can directly influence the end of some of those all-important beta cells. 

Upon loss of beta cells, the infection also seems to alter the destiny of the surviving cells. Chen's team conducted single-cell investigation to get a detailed look at disparities in the gene activity within pancreatic cells following SARS-CoV-2 infection. These studies revealed that beta cells undergo a procedure of transdifferentiating, in which they seemed to get reprogrammed.


In this process, the cells start producing less insulin and more glucagon, a hormone that promotes glycogen in the liver to break down into glucose. They also started producing more increased levels of a digestive enzyme called trypsin 1. Notably, they also revealed that this transdifferentiating procedure could be reversed by a chemical (called trans-ISRIB) known to ease an important cellular response to stress.


Though this transdifferentiating of beta cells are not yet evident, but would be expected to depreciate insulin deficiency and increase blood glucose levels. More study is required to understand how SARS-CoV-2 gets the pancreas and what function the immune system might play in the resultant damage. Above all, this work delivers yet another reminder of the significance of safeguarding yourself, your friends and family members, your community from COVID-19.

Read more about the diabetes researches conducted by the best diabetologists in Kuwait :

قيس

الامانة العامة لمجلس الوزراء

البنك التجاري الكويتي

Diabetes symptoms

Almulla group

Dasma health center



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Location: Kuwait

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